Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors

Filoviruses infect a wide range of cell types with the exception of lymphocytes.The intracellular proteins cathepsin B and L, two-pore channel 1 and 2, and bona fide receptor Niemann–Pick Disease C1 (NPC1) are essential for the endosomal phase of cell entry.However, earlier steps of filoviral infection remain poorly characterized.Numerous pla

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